Mechanisms of Biliary Damage

Mechanisms of Biliary Damage

Bile duct damage is present in virtually all cholangiopathies, which share the biliary epithelial cells (i.e. cholangiocytes) as a common pathogenic target. Cholangiocyte cell death largely occurs through the process of apoptosis. In this review, we will summarize the mechanisms through which biliary damage occurs in a variety of animal and in vitro models, such as extrahepatic cholestasis indu...

Mechanisms Generating Biliary Lipid Specificity

This thesis addresses the molecular processes which are important in the formation of bile fluid. The polar liver cells (hepatocytes) secrete the bile fluid at their apical (canalicular) membrane into tubular bile canaliculi (BC) which are formed between adjacent cells. The basolateral membrane of hepatocytes faces the blood vessel. Bile fluid possesses a remarkable specificity regarding its li...

Mechanisms of ischemic brain damage.

In the United States stroke is the third leading cause of death and the leading cause of disability. Brain injury following stroke results from the complex interplay of multiple pathways including excitotoxicity, acidotoxicity, ionic imbalance, peri-infarct depolarization, oxidative and nitrative stress, inflammation and apoptosis. There are very few treatments for stroke and the development of...

assessment of the park- ang damage index for performance levels of rc moment resisting frames

چکیده هدف اصلی از طراحی لرزه ای تامین ایمنی جانی در هنگام وقوع زلزله و تعمیر پذیر بودن سازه خسارت دیده، پس از وقوع زلزله است. تجربه زلزله های اخیر نشان داده است که ساختمان های طراحی شده با آیین نامه های مبتنی بر نیرو از نظر محدود نمودن خسارت وارده بر سازه دقت لازم را ندارند. این امر سبب پیدایش نسل جدید آیین نامه های مبتنی بر عملکرد شده است. در این آیین نامه ها بر اساس تغییرشکل های غیرارتجاعی ...

Biliary Disease Damage in Nonobese Diabetic Autoimmune CD8 T Cells Mediate Direct Biliary Ductule